NeuroMab™ Mouse Anti-Human PDCD6IP Monoclonal Antibody (CBP1606)

Description

Mouse anti-human ALIX antibody recognizes apoptosis 6 interacting protein, also known as ALG-2 interacting protein 1, ALG-2 interacting protein X, PDCD6 interacting protein, apoptosis-related gene 2-interacting protein X, Dopamine receptor interacting protein 4 and programmed cell death 6 interacting protein.
The PDCD6IP (ALIX) gene encodes a protein that plays a role in the ESCRT pathway during the shedding phase of cytokinesis, the formation of endosomal vesicles in the cavity, and the budding of enveloped viruses. Studies using mouse cells have shown that overexpression of this protein can prevent cell apoptosis. In addition, the product of PDCD6IP binds to the product of PDCD6 gene in a calcium-dependent manner, and PDCD6 gene is a protein required for cell apoptosis. The PDCD6IP product also binds to endocytic proteins, which regulate the shape of the membrane during endocytosis. Overexpression of PDCD6IP products and endorphins leads to vacuolation of the cytoplasm, which may be partly a protective effect against cell death. For PDCD6IP, several transcript variants encoding alternative splicing of different isoforms have been discovered. A related pseudogene has been identified on chromosome 15 (provided by RefSeq, January 2012).

Immunogen

Full length recombinant human ALIX (NP_037506) produced in HEK293T cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP1606

Applications

WB

Application Notes

WB (1/1000)

Research Areas

Growth and Development

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1381

Form

Liquid

Formulation

PBS
0.09% Sodium Azide
1% BSA
≤50% Glycerol

Purification

Mouse monoclonal antibody purified by affinity chromatography from ascites.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

ALIX

Official Name

PDCD6IP

Full Name

Programmed Cell Death 6 Interacting Protein

Alternative Names

Programmed Cell Death 6 Interacting Protein; Programmed Cell Death 6-Interacting Protein; ALG-2-Interacting Protein X; PDCD6-Interacting Protein; AIP1; HP95; ALIX; Apoptosis-Linked Gene 2-Interacting Protein X

Gene ID

10015(Human); 18571(Mouse); 501083(Rat)

Uniprot ID

Q8WUM4(Human); Q9WU78(Mouse); Q9QZA2(Rat)