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NeuroMab™ Mouse Anti-Human PDCD6IP Monoclonal Antibody (CBP1606)
Mouse Monoclonal [1A4] to PDCD6IP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
The PDCD6IP (ALIX) gene encodes a protein that plays a role in the ESCRT pathway during the shedding phase of cytokinesis, the formation of endosomal vesicles in the cavity, and the budding of enveloped viruses. Studies using mouse cells have shown that overexpression of this protein can prevent cell apoptosis. In addition, the product of PDCD6IP binds to the product of PDCD6 gene in a calcium-dependent manner, and PDCD6 gene is a protein required for cell apoptosis. The PDCD6IP product also binds to endocytic proteins, which regulate the shape of the membrane during endocytosis. Overexpression of PDCD6IP products and endorphins leads to vacuolation of the cytoplasm, which may be partly a protective effect against cell death. For PDCD6IP, several transcript variants encoding alternative splicing of different isoforms have been discovered. A related pseudogene has been identified on chromosome 15 (provided by RefSeq, January 2012).
Immunogen
Species Reactivity
Clonality
Host Species
Isotype
Clone Number
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Application Notes
Research Areas
Conjugation
Form
Formulation
0.09% Sodium Azide
1% BSA
≤50% Glycerol
Purification
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Shipping
Storage
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Target
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Publications (0)
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