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Creative Biolabs

NeuroMab™ Mouse Anti-FOX3 Monoclonal Antibody (CBP2198)

[CAT#: NAB201064LS]

Anti-FOX3 Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
IHC-P; WB; ICC; IHC-Fr

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Product Overview

Description

Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46 kD proteins, each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. Fox3 is a protein which has a function in RNA splicing and is expressed heavily and specifically in neuronal nuclei. The 1B7 antibody reveals strong nuclear and distal cytoplasmic staining for Fox3/NeuN and the complete absence of staining of astrocytes and other kinds of non-neuronal cells. This Fox3/NeuN antibody is therefore an excellent marker of neuronal cells.

Immunogen

Antibody was raised against the N-terminal 100 amino acids of human Fox3 as expressed in and purified from E. coli.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2198

Applications

IHC-P; WB; ICC; IHC-Fr

Application Notes

IHC(0.5-1.0 µg/mL); WB (0.01-0.05 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1629
Product Properties

Form

Liquid

Formulation

PBS, containing 10mM sodium azide.

Concentration

1.0 mg/ml

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

FOX3

Official Name

RBFOX3

Full Name

RNA binding protein, fox-1 homolog (C. elegans) 3

Alternative Names

RBFOX3; FOX-3; FOX3; HRNBP3; NEUN; RNA binding protein; fox-1 homolog 3; uncharacterized LOC644767

Gene ID

146713 (Human);

Uniprot ID

A6NFN3 (Human);
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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