NeuroMab™ Mouse Anti-Musashi-1 Monoclonal Antibody (CBP2503)

Product Overview

Description

Musashi-1 (MSI1) is an evolutionarily conserved RNA-binding protein with essential role in stem cell maintenance, nervous system development, and tumorigenesis. It was first identified in Drosophila as a protein required for the development of adult external sensory organs (sensilla) and neuronal potential in asymmetric cell division. In mammalian nervous systems, MSI1 is one of the key oncogenic factors for glioblastomas and medulloblastomas. The expression of MSI1 is associated with Notch signaling. The high expression of MSI1 is a marker of poor prognosis in medulloblastoma. Genomic analysis indicates that MSI1 functions as a master regulator of genes during development and tumor formation.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2503

Applications

IHC-P

Application Notes

IHC-P (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1832

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Musashi 1

Official Name

MSI1

Full Name

Musashi-1

Alternative Names

MSI1; musashi RNA binding protein 1

Gene ID

4440(Human)

Uniprot ID

O43347(Human)

References

1. Okabe M, et al. 2001. Nature. 411:94-8.
2. de Sousa Abreu R. et al. 2009. J Biol Chem. 284(18):12125-35.
3. Vo DT. et al. 2012. Am J Pathol. 181(5):1762-72.
4. Sengupta U. et al. 2018. Acta Neuropathol Commun. 6(1):113.

Publications