NeuroMab™ Mouse Anti-CD209 Monoclonal Antibody (CBP2573)

Product Overview

Description

Mouse anti-human CD209 antibody, recognizes human DC-specific ICAM-3 capture non-integrin (DC-SIGN), a C-type lectin of approximately 45 kDa that binds to ICAM-3, also known as CD209. CD209 is mainly expressed on immature dendritic cell populations and immature myeloid monocyte-derived DCs in vitro. CD209 is involved in the migration of dendritic cells (DC) and the initial interaction between DC and naive T lymphocytes. CD209 also binds to HIV-1 gp120 and plays a key role in the transmission of HIV-1 by DC. Mouse anti-human CD209 antibody, clone MR-1 is reported to partially block the functional activity of DC-SIGN.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2573

Applications

Application Notes

FC: 1/5

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1873

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.1 mg/ml

Purification

Protein A

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD209a

Official Name

CD209

Full Name

CD209 Molecule

Alternative Names

CD209 Molecule; CD209 Antigen; Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 1; C-Type Lectin Domain Family 4 Member L; DC-SIGN1; DC-SIGN;

Gene ID

30835(Human); 170780(Mouse)

Uniprot ID

Q9NNX6(Human); Q91ZW7(Mouse)

References

1. Melero, I. et al. (2002) An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas.
2. Domínguez-Soto, A. et al. (2011) Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10.
3. Chang, S.K. et al. (2008) B lymphocyte stimulator regulates adaptive immune responses by directly promoting dendritic cell maturation.

Publications