NeuroMab™ Mouse Anti-CD38 Monoclonal Antibody (CBP3008)

Product Overview

Description

CD38 is a type II transmembrane glycoprotein with a short N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites (PMID: 2319135). The extracellular domain of CD38 has bifunctional enzyme activities that catalyze synthesis of cyclic ADP ribose from nicotinamide adenine dinucleotide (NAD) and hydrolysis of cyclic ADP ribose to adenosine diphosphoribose (PMID: 10636863). CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis.

Expression Host

Mammalian cells

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP3008

Applications

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1901

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

5 µl(0.25µg)/test

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD38

Official Name

CD38

Full Name

CD38 molecule

Alternative Names

Acute lymphoblastic leukemia cells antigen CD38;
ADP ribosyl cyclase 1;
ADP ribosyl cyclase;
ADP ribosyl cyclase/cyclic ADP-ribose hydrolase;
ADP-ribosyl cyclase 1;
ADPRC 1;
ADPRC1;
cADPr hydrolase 1;
CD 38;

Gene ID

952(Human)

Uniprot ID

P28907(Human)

References

1. Liao, S., Xiao, S., Zhu, G., Zheng, D., He, J., Pei, Z.,... & Zhou, Y. (2014). CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. Oncology reports, 32(6), 2703-2709. 2. Bai, H., Zhu, H., Yan, Q., Shen, X., Lu, X., Wang, J.,... & Chen, L. (2018). TRPV2-induced Ca 2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma. Cell Communication and Signaling, 16(1), 68.

Publications