NeuroMab™ Mouse Anti-TUBB3 Monoclonal Antibody (CBP308)

Description

The 2G10-TB3 antibody reacts with β-tubulin III (a structural protein of approximately 50-55 kDa, a component of tubulin). Tubulin is the main component of microtubules in the cytoskeleton, assembled from heterodimers of α- and β-tubulin subunits. The βIII subtype of tubulin, also known as neuron-specific class III β-tubulin, is mainly expressed in neurons and is widely used as a marker to distinguish neurons from other cell types. Beta-tubulin III contributes to the formation of microtubules in neuronal cell bodies and axons. This function involves GTP binding and plays a role in axonal transport, neuronal cell proliferation and differentiation. It is highly expressed in several types of cancer and is a predictor and prognostic marker for various tumors, for example, it is not found in tumors but in normal glial cells. The 2G10-TB3 antibody is expected to recognize all mammalian homologues of β-tubulin III, and it is reported that the epitope is located at the C-terminal extreme amino acid EAQGPK.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, kappa

Clone Number

CBP308

Applications

FC; ICC; IF; IHC; IP; WB

Application Notes

Assay dependent

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 578

Form

Liquid

Purity

>95%

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Notes: avoid repeated freeze-thaw cycles.

Research Use Only

NAB-0720-Z949 is designed for research use only, not for diagnostic or therapeutic use.

Target

Tubulin β 3

Official Name

TUBB3

Full Name

Class III β-tubulin

Alternative Names

TUBB3; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; TUBB4; beta-4; tubulin beta 3 class III

Gene ID

10381(Human);22152(Mouse)

Uniprot ID

Q13509(Human)