Mouse Anti-TUBB3 Monoclonal Antibody (CBP2755)

Product Overview

Description

TUBB3 is selectively expressed in testis and neurons of the central and peripheral nervous system. It has been widely used as a marker for neurons. Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy. This antibody is specific to TUBB3 but not cross-react with other tubulin isoforms.

Expression Host

Mammalian cells

Immunogen

Peptide

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2755

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neurotransmission

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Tubulin β 3

Official Name

TUBB3

Full Name

Tubulin, beta 3

Alternative Names

Beta tubulin; MC1R; TUBB; Tubulin-beta

Gene ID

10381(Human); 22152(Mouse); 246118(Rat)

Uniprot ID

Q13509(Human); Q9ERD7(Mouse)

References

1. Hei, Z., Wu, S., Liu, Z., Wang, J., & Fang, P. (2019). Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. Journal of Biological Chemistry, 294(13), 4775-4783. 2. Wang, Q., Tian, J., Chen, H., Du, H., & Guo, L. (2019). Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement. Neurobiology of disease, 127, 410-418. 3. Gao, P., Li, N., Ji, K., Wang, Y., Xu, C., Liu, Y.,... & Du, L. (2019). Resveratrol targets TyrRS acetylation to protect against radiation-induced damage. The FASEB Journal, 33(7), 8083-8093.

Publications