Human 1321N1/P2Y12/Gα15 Stable Cell Line

[CAT#: NCL20120110CR]

P2Y12 Purinergic Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The P2Y receptor 12 is a Gi-coupled GPCR expressed in platelets, brain tissues, vascular smooth muscle cells. P2Y12 can sustain platelet aggregation and promote thrombus growth and stabilization. It also plays a function in dense and alpha granule secretion, p-selectin expression and microparticle formation.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 50 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

P2Y12

Family

P7Y receptor

Strain

1321N1/P2Y12/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

P2Y12

Official Name

P2Y12

Alternative Names

P2Y12 receptor; P2T; P2YAC; P2TAC; P2Y?; P2Ycyc; SP1999; P2YADP; P2T; P2Y12; HORK3; P2Y purinoceptor 12; P2Y12 platelet ADP receptor; purinergic receptor P2Y; G-protein coupled 12; 2900079B22Rik; 4921504D23Rik

Gene ID

70839(Mouse); 64803(Rat)

Uniprot ID

Q9CPV9(Mouse); Q9EPX4(Rat)

References

1. Mi, G., Liu, S., Zhang, J., Liang, H., Gao, Y., Li, N.,.. & Yang, Z. (2017). Levo-tetrahydroberberrubine produces anxiolytic-like effects in mice through the 5-HT 1A receptor. PloS one, 12(1), e0168964.

Publications