Human CHO-K1/ADRA1B Stable Cell Line

[CAT#: NCL20120018CR]

ADRA1B Adrenoceptors Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Α1-ARs belong to the G protein-coupled receptor family and consist of single polypeptide chains that are predicted to form seven transmembrane spanning domains. With similar pharmacological and signaling properties, α1-AR subtypes act through Gq/11 proteins to activate phospholipase C, increase inositol 1,4,5-trisphosphate production, and increase intracellular Ca2+. ADRA1B functions in diverse settings include vasoconstriction and myocardial contractility, neuronal dopaminergic responses, dendritic cell migration and inflammatory responses, as well as neuroendocrine regulation of fertility.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

ADRA1B

Family

Adrenoceptors

Strain

ADRA1B Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

ADRA1B

Official Name

ADRA1B

Full Name

Alpha-1B adrenoceptor

Alternative Names

Alpha-1B adrenoceptor; Alpha-1b; adrenergic; alpha-1B-; receptor; adrenergic receptor; alpha 1b; alpha 1B-adrenoceptor; alpha-1B adrenergic receptor

Gene ID

147(Human); 11548(Mouse); 24173(Rat)

Uniprot ID

P35368(Human); P97717(Mouse); P15823(Rat)

References

1. Yang, E. L., Sun, B., Huang, Z. Y., Lin, J. G., Jiao, B., & Xiang, L. (2019). Synthesis, Purification, and Selective β2-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from Portulaca oleracea. Journal of Natural Products, 82(11), 2986-2993.

Publications