Human CHO-K1/FFA1/Gα15 Stable Cell Line

[CAT#: NCL20120061CR]

Free Fatty Acid Receptor 1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Free fatty acid G protein coupled receptor family consists of four members and plays significant roles in nutrition regulation. GPR40 and GPR120 are activated by medium and long-chain FFAs, whereas GPR41 and GPR43 can be activated by short-chain FFAs. GPR40 is preferentially expressed in pancreatic beta-cells and mediates the majority of the effects of FFAs on insulin secretion. Researches show that GPR40 is a potential therapeutic target and plays an important role in the chain of events linking obesity and type2 diabetes.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

GPR40/FFA1

Family

Free fatty acid receptor

Strain

FFA1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

FFA1

Official Name

FFA1

Alternative Names

FFA1 receptor; FFAR1; GPR40; FFA1R; G protein-coupled receptor 40; G-protein coupled receptor 40; free fatty acid receptor 1

References

1. West, R., Valentin, C., & Herr, C. (2008). 270 STILL GLOWING AFTER ALL THESE YEARS: STORAGE LIFE OFA COMPLETE BOVINE SEXING PCR MIX. Reproduction, Fertility and Development, 20(1), 215-215. 2. Valentin, C., West, R., & Herr, C. (2008). 269 THE ENHANCEMENT OF THE SENSITIVITY OF A PCR-BASED AVIAN SEX DETERMINATION ASSAY. Reproduction, Fertility and Development, 20(1), 214-215.

Publications