Human CHO-K1/MCH2 Stable Cell Line

[CAT#: NCL20120083CR]

Melanin-concentrating Hormone Receptor 2 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Coupled exclusively Gq, MCH2 is a receptor for melanin-concentrating hormone. Other than regulating skin color, two subtypes (MCHR1 and MCHR2) are involved in energy homeostasis and social behaviors. In contrast to MCHR1 that is conserved among all mammals, functional MCHR2 is only expressed in carnivores and primates, but not in rodents.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 500 µg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

MCH2/GPR145

Family

Melanin concentrating hormone receptor

Strain

MCH2 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

MCH2

Official Name

MCH2

Alternative Names

MCH2 receptor; S643b; GPR145; gpr 145; MCHR2; MCH-2R; SLT; GPRv17; MCH2; MCH2R; G protein-coupled receptor 145

Gene ID

84539(Human)

Uniprot ID

Q969V1(Human)

References

1. Ma, T. C., Vong, K. I., & Kwan, K. M. (2020). Spatiotemporal Decline of BMP Signaling Activity in Neural Progenitors Mediates Fate Transition and Safeguards Neurogenesis. Cell Reports, 30(11), 3616-3624. 2. Ding, C., Chan, D. W., Liu, W., Liu, M., Li, D., Song, L.,.. & Zhen, B. (2013). Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements. Proceedings of the National Academy of Sciences, 110(17), 6771-6776. 3. Freschi, L., Torres-Quiroz, F., Dubé, A. K., & Landry, C. R. (2013). qPCA: a scalable assay to measure the perturbation of protein-protein interactions in living cells. Molecular BioSystems, 9(1), 36-43.

Publications