Product

Human CHO-K1/NK1 Stable Cell Line

[CAT#: NCL20120129CR]

NK1 Tachykinin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: CHO-K1; GPCR Cell

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Product Overview

Description

NK1 mediates endothelium-dependent vasodilatation and plasma protein extravasations. In the gastrointestinal system, NK1 receptors mediate intestinal motility, secretion, and vascular functions. SP-NK1 receptor communication is also involved in glioma development and progression. NK1 receptor antagonists may have several therapeutic applications in diseases mediated by tachykinins, such as pulmonary disorders, gut disorders, and the pathophysiology of depression.

Cell Types

CHO-K1; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

NK1/TACR1

Family

Tachykinin receptor

Strain

NK1 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

NK1

Official Name

NK1

Alternative Names

NK1 receptor; SPR; NK1-R; Substance P receptor; Substance P; TAC1R; NK1R; NKIR; NK-1 receptor; NK-1R; Tachykinin 1 receptor; Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor); Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor) see also D4Mgh17 D4Wox19 and D4Mit23; neurokinin 1 receptor; substance-P receptor; tachykinin receptor 1; NK1 receptor; neurokinin receptor 1

Gene ID

27087(Human); 76898(Mouse); 117108(Rat)

Uniprot ID

Q9P2W7(Human); Q9CW73(Mouse); O35789(Rat)

References

1. Bobik, T. A., Morales, E. J., Shin, A., Cascio, D., Sawaya, M. R., Arbing, M.,.. & Rasche, M. E. (2014). Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii. Acta Crystallographica Section F: Structural Biology Communications, 70(11), 1472-1479.

Publications