Human CHO-K1/OPRM1/Gα15 Stable Cell Line

[CAT#: NCL20120101CR]

μ-Opioid Receptor OPRM1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The µ-opioid receptor (oprm1) is the principal site of action in the brain by which morphine, other opiate drugs of abuse, and endogenous opioid peptides effect analgesia and alter mood. Opioid receptors belong to the rhodopsin family of G protein-coupled receptors (GPCRs). The three types of opioid receptors (μ, δ, and κ) have been shown to associate with each other in a homotypic or heterotypic fashion when expressed in heterologous cells.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

OPRM1

Family

Opioid & opioid-like receptor

Strain

OPRM1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

Mu Opioid Receptor

Official Name

OPRM1

Alternative Names

MOR-1; Mu opioid receptor; OP3; MOP; MOR; MOR1; MORA; Oprm; Oprrm1; M-OR-1; MUOR1; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; mu-type opioid receptor; opioid receptor B; muOR; MOP receptor; MOP-R; MOP-r

Gene ID

4988(Human); 18390(Mouse); 25601(Rat)

Uniprot ID

P35372(Human); P42866(Mouse); P33535(Rat)

References

1. Yang, P. P., Yeh, G. C., Yeh, T. K., Xi, J., Loh, H. H., Law, P. Y., & Tao, P. L. (2016). Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice. Pharmacological research, 111, 867-876.

Publications