NeuroMab™ Anti-CD3 BBB Shuttle Antibody(NRZP-1022-ZP3915)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

FC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD3

Official Name

CD3

Full Name

CD3e molecule, epsilon (CD3-TCR complex)

Alternative Names

CD3; CD3e molecule; epsilon (CD3-TCR complex)

Product Pictures

FCM

Figure 1 Flow cytometric analysis of PG3055 and PG3056 binding to CD3 on purified human T cells after incubation of PG3055 and PG3056 in IMDM+10% FBS medium for 7 days at 2-8°C or 37°C.

FCM

Figure 2 Flow cytometry analysis of the binding of variants PG3872, PG3873 and PG3905 to CD3 on HPB-ALL cells with PG3056 as a baseline control

FCM

Figure 3 Flow cytometry analysis of CD3 on HPB-ALL cells binding variants PG3874, PG3878, PG3883, PG3886 and PG3891, including PG3056 as a baseline control.

FCM

Figure 4 Flow cytometry analysis of PG5192-5197 variant HPB-ALL cells binding to CD3, PG3056 as a baseline control

FuncS

Figure 5 Binding of 5196×4327 DM-Fc bsAb to membrane-expressed CD3 (HPB-ALL) and CLEC12A (HL-60)

FuncS

Figure 6 5196×4327 DM-Fc bsAb retained CLEC12A-specific activation of CD4 and CD8 T cells, as reflected by upregulation of the early activation marker CD69.