NeuroMab™ Anti-LAG3 BBB Shuttle Antibody(NRZP-1022-ZP3026)
[CAT#: NRZP-1022-ZP3026]
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- ELISA; Inhib; In Vitro
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Humanized
Applications
ELISA; Inhib; In Vitro
Relevant Diseases
Parkinson's Disease
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
LAG3
Official Name
LAG3
Full Name
lymphocyte-activation gene 3
Alternative Names
CD antigen CD223; CD223; Protein FDC; Lymphocyte activation gene 3 protein; LAG-3
Product Pictures
ELISA
Figure 1 ELISA results showing EC50 of antibody binding to LAG3 intact extracellular domain (D1-D4 huFc) but not D1-D2 deleted LAG3 (△D1-D2 huFc).
Inhib
Figure 2 Dose-dependent inhibition of the binding of LAG3 to its receptor MHC class II molecules.
FuncS
Figure 3 122H, 147H, and 170H mouse mAbs dose-dependently promote IL2 production by Jurkat T cells.
FuncS
Figure 4 Humanized monoclonal antibody 147H-13 dose-dependently promotes the production of IL2 by Jurkat T cells.
FuncS
Figure 5 Effect of affinity matured anti-LAG3 antibody on stimulation of IL2 release from Jurkat T cells.
Block
Figure 6 Anti-LAG3 antibody blocks the binding of Galectin-3 or LSECtin to LAG3.
Block
Figure 7 The combination of anti-LAG3 antibody and anti-PD-L1 antibody produced significantly more IL-2 than each alone.
Block
Figure 8 Combination of anti-PD-L1 antibody and 147H-13 shows strong inhibition of MC38 tumor growth.
Publications
Publications (0)
Neural Antibodies
Kits
For Research Use Only. Not For Clinical Use.
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