NeuroMab™ Anti-Notch 1 Antibody,Clone NR3423P

Product Overview

Description

The antibody specifically binds to human Notch1, but not mouse Notch1. The antibody binds to at least two epitopes, wherein one epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the other epitope resides within the HD-C domain of the Notch1 NRR. mAb N248A exhibits potent in inhibiting Dll4 ligand-induced Notch1 signaling.

Epitope

Nanobody/VHH

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

NR3423P

Applications

WB; DB; Inhib; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Epilepsy; Pain

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Notch1

Official Name

NOTCH1

Full Name

NOTCH1

Alternative Names

Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1; Translocation-Associated (Drosophila); Notch Homolog 1; Translocation-Associated;