NeuroMab™ Anti-TARPGamma2/Stargazin BBB Shuttle Antibody, Clone N245/1

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNG2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 203-323 (cytoplasmic C-terminus) of rat TARPGamma2 (also known as Voltage-dependent calcium channel gamma-2 subunit, Neuronal voltage-gated calcium channel gamma-2 subunit, Stargazin and Stg, accession number Q71RJ2)
Mouse: 100% identity (121/121 amino acids identical)
Human: 96% identity (117/121 amino acids identical)
>50% identity with TARPGamma3, TARPGamma4 and TARPGamma8

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N245/1

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with TARPGamma3, TARPGamma4 and TARPGamma8

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNG2

Official Name

CACNG2

Full Name

TARPGamma2/Stargazin

Alternative Names

CACNG2 Antibody, Calcium channel voltage dependent gamma subunit 2 Antibody, CaV gamma 2 Antibody, Ipr328 Antibody, MGC123981 Antibody, MGC138502 Antibody, MGC138504 Antibody, Voltage-dependent calcium channel gamma-2 subunit Antibody, Neuronal voltage-gated calcium channel gamma-2 subunit Antibody, Stargazin Antibody, Stg Antibody, Stargazer Antibody, TARP Antibody, TARP gamma-2 Antibody, Transmembrane AMPAR regulatory protein gamma-2 Antibody, AW060990 Antibody, B230105C07Rik Antibody, B930041E13Rik Antibody, Wag Antibody, Waggler Antibody; Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2; Neuronal Voltage-Gated Calcium Channel Gamma-2 Subunit; Transmembrane AMPAR Regulatory Protein Gamma-2; TARP Gamma-2; Calcium Channel, Voltage-Dependent, Gamma Subunit 2; Voltage-Dependent Calcium Channel Gamma-2 Subunit; Stargazin; MRD10