NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP2749)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; In Vitro; Agonist

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Product Pictures

FuncS

Figure 1 is a graph showing dose-response curves of TREM-2 activation in response to treatment with anti-TREM-2 antibodies HJ23.4, HJ23.7, HJ23.8, HJ23.9, HJ23.10 and HJ23. 13. TREM- 2 Activation is reported as % GFP relative to negative control (y-axis).

Publications