NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P811)

Product Overview

Description

The antibody specifically binds to a human triggering receptor expressed on myeloid cells 2 (TREM2) and useful in preventing, reducing risk, or treating an individual in need.

Immunogen

Mouse Fc Fused Human TREM2 ECD

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; ELISA; Block; Inhib; In Vitro; In Vivo; Agonist

Relevant Diseases

Alzheimer's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Gene ID

54209(Human)

Uniprot ID

Q9NZC2(Human)

Product Pictures

FCM

Figure 1 Binding of anti-TREM2 antibodies to primary human macrophages.

FuncS

Figure 2 Anti-TREM2 antibody induces human macrophage survival.

Human monocytes isolated from peripheral blood were incubated with 5 ng/mL M-CSF in the presence of titrated concentrations of plate-coated anti-TREM2 antibody or an isotype control. On day 6, cell viability was determined by the CellTiter Glo Viability Assay. Anti-TREM2 antibodies increase the survival of human macrophages cultured in limited or no M-CSF.