NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P812)

Product Overview

Description

The antibody specifically binds to a human triggering receptor expressed on myeloid cells 2 (TREM2) and useful in preventing, reducing risk, or treating an individual in need.

Immunogen

Mouse Fc Fused Human TREM2 ECD

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; ELISA; Block; Inhib; In Vitro; In Vivo; Agonist

Relevant Diseases

Alzheimer's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Gene ID

54209(Human)

Uniprot ID

Q9NZC2(Human)

Product Pictures

ELISA

Figure 1 Anti-TREM2 antibody activates P-Syk.

Determining the P-Syk Activating Dose Response of Anti-TREM2 Antibodies. Anti-TREM2 antibodies were dose titrated to HEK cells expressing human TREM2, and pSyk induction was calculated as a buffer control fold. EC50 values show the nM potency and fold induction of pSyk for each antibody.

FuncS

Figure 2 Anti-TREM2 antibody induces human macrophage survival.

FuncS

Figure 3 Signaling pathway induced by anti-TREM2 antibody.

Human macrophages were stimulated with 30 nM antibody or control for 15 minutes. p-Y525/526-SYK of cell lysates was measured by Alpha-LISA. Anti-TREM2 antibody induces Syk phosphorylation, ERK phosphorylation, GSK3-β phosphorylation and AKT phosphorylation.

Publications