NeuroMab™ Hamster Anti-ITGAM Monoclonal Antibody (CBP1550)

Product Overview

Description

It recognizes the murine integrin β1 subunit (CD29), a cell surface glycoprotein of approximately 110 kDa, which is widely expressed by a variety of cells including all leukocytes. CD29 forms a non-covalent bond with the α subunit of integrin including CD51 and CD49a-f to form a heterodimer. The ligands of these heterodimers include collagen, fibronectin, laminin and vascular adhesion molecule-1. In the immune system, β1 integrin plays an important role in cell adhesion, migration, activation and differentiation.

Immunogen

Mouse VLA-4.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Host Species

Hamster

Isotype

IgG

Clone Number

CBP1550

Applications

Application Notes

FCM (1/10)

Research Areas

Growth and Development

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1348

Product Properties

Form

Liquid

Formulation

PBS
0.09% Sodium Azide
1% BSA

Concentration

0.5 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

Target

CD11b

Official Name

ITGAM

Full Name

Integrin alpha M

Alternative Names

ITGAM; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; integrin subunit alpha M

Gene ID

3684 (Human); 16409 (Mouse); 25021 (Rat)

Uniprot ID

P11215 (Human); P05555 (Mouse)

References

1. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb. 2. Lu, T.Y. et al. (2010) Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. 3. Li S et al. (2010) Upregulation of CXCR4 favoring neural-like cells migration via AKT activation. 4. Eto, D.S. et al. (2007) Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. 5. Tiede, B.J. et al. (2009) A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy. 6. Kouros-Mehr H (2008) GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. 7. Xu, L. et al. (2017) Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars.

Publications