NeuroMab™ Rat Anti-Myelin Protein Zero Monoclonal Antibody (CBP2231)

Product Overview

Description

Myelin protein zero (MPZ), is a membrane glycoprotein mainly expressed in the peripheral nervous system (PNS). It is the major structural component of the myelin sheath, and accounts for at least 50% of all proteins in the PNS. MPZ is expressed by Schewann cells. Mutations in MPZ have been associated with myelin deficiency, which may lead to neuropathies including charcot-Marie-Tooth and Dejerine-Sottas diseases.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b, κ

Clone Number

CBP2231

Applications

WB; IHC-P

Application Notes

WB (1-5 µg/mL); IHC (5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1656

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Myelin Protein Zero

Official Name

MPZ

Full Name

Myelin Protein Zero

Alternative Names

MPZ; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; P0; myelin protein zero; CHN2

Gene ID

9019(Human)

Uniprot ID

O95297(Human)

References

1. Chiò A and Lauria G. 2016. Lancet Neurol. 15(1):12
2. Brennan KM, et al. 2015. Neurosci Lett. 596:14
3. Tazir M, et al. 2014. J Neurol Sci. 347(1-2):14

Publications