Mouse Anti-UCHL1 Monoclonal Antibody (CBP6809)

Description

Neuroinflammation broadly defines the collective response Immune response in the brain and spinal cord Injuries and illnesses. Central nervous system inflammation (CNS) Usually related to different levels of organization Damage, such as loss of myelin sheath and neurons. Ubiquitin carboxyl terminal hydrolase L1 (EC 3.1.2.15, Ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme.UCH-L1 is a member of a gene family whose products hydrolyze the small C-terminal adduct of ubiquitin to produce ubiquitin monomers. The expression of UCH-L1 is highly specific for neurons and cells of the diffuse neuroendocrine system and their tumors. It is widely present in all neurons (about 1-2 of total brain protein) and is specifically expressed in neurons and testes/ovaries. The catalytic triad of UCH-L1 contains cysteine at position 90, aspartic acid at position 176, and histidine at position 161, which is the reason for its hydrolase activity.

Epitope

Binds to an located within the peptide sequence AVANNQDKLG

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6809

Applications

IHC; WB; IF

Application Notes

IHC: 1:5000-1:10000
WB: 1 µg/ml
IF: 2-10 µg/ml

Research Areas

Neuron

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

PGP9.5

Official Name

UCHL1

Full Name

Ubiquitin carboxy-terminal hydrolase L1

Alternative Names

UCHL1; HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1; HEL-S-53; ubiquitin C-terminal hydrolase L1; SPG79

Gene ID

7345(Human); 22223(Mouse); 29545(Rat)

Uniprot ID

P09936(Human); Q9R0P9(Mouse); Q00981(Rat)