Human CHO-K1/GPR103/Gα15 Stable Cell Line

[CAT#: NCL20120112CR]

G-Protein Coupled Receptor 103 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

GPR103 can express in brain, heart, kidney, adrenal gland, retina, and testis. GPR103 mRNA has been reported to be highly expressed in the superficial layers of the entire spinal cord and a high density of 26RFa binding sites was observed in the superficial layers of the dorsal horn. QRFP binds and activates the human GPR103, as well as mouse GPR103A and GPR103B, with nanomolar affinities in transfected cells. Therefore, the current experiments investigated the effects of QRFP administration in rats and the effects of a high fat diet on prepro-QRFP mRNA and GPR103 receptor mRNA levels. 26RFa and QRFP are endogenous ligands of GPR103.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

QRFP/GPR103

Family

Peptide P518 receptor

Strain

GPR103/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

GPR103

Official Name

GPR103

Alternative Names

QRFP receptor; SP9155; AQ27; GPR103; G-protein coupled receptor 103; G protein-coupled receptor 103

Gene ID

84109(Human); 229214(Mouse); 310327(Rat)

Uniprot ID

Q96P65(Human); P83861(Mouse); P83858(Rat)

References

1. Ghosh, E., Dwivedi, H., Baidya, M., Srivastava, A., Kumari, P., Stepniewski, T.,.. & Roy, D. (2019). Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms. Cell reports, 28(13), 3287-3299. 2. Hernandez-Gordillo, V., & Chmielewski, J. (2014). Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds. Biomaterials, 35(26), 7363-7373.

Publications