Human CHO-K1/GRM2/Gα15 Stable Cell Line

[CAT#: NCL20120090CR]

Metabotropic Glutamate Receptor 2 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. GRM2 is linked to the inhibition of the cyclic AMP cascade, included in group II metabotropic glutamate receptors.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

mGlu2/GRM2

Family

Metabropic glutamate receptor

Strain

GRM2/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

mGluR2

Official Name

GRM2

Alternative Names

mGlu2 receptor; mGluR2; GPRC1B; mGlu2; Grm2; glutamate receptor; metabotropic 2; metabotropic glutamate receptor 2; 4930441L02Rik

Gene ID

2912(Human); 108068(Mouse); 24415(Rat)

Uniprot ID

Q14416(Human); Q14BI2(Mouse); P31421(Rat)

References

1. Cui, J., Wang, H., Medina, R., Zhang, Q., Xu, C., Indig, I. H.,.. & Guo, L. (2020). Inhibition of PP2A with LB-100 enhances efficacy of CAR-T cell therapy against glioblastoma. Cancers, 12(1), 139. 2. Matvienko, D. A., Kulemzin, S. V., Smagina, A. S., Belovezhets, T. N., Chikaev, A. N., Volkova, O. Y.,.. & Gorchakov, A. A. (2018). Analysis of in vitro activity of PSCA-specific CARs in the context of human NK cell line YT. Cell Ther. Transplant., 7, 70-76. 3.

Publications