Human CHO-K1/MC4/Gα15 Stable Cell Line

[CAT#: NCL20120086CR]

MC4 Melanocortin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The melanocortin family consists of five melanocortin G-Protein-coupled receptors (designated MC1-5R). The melanocortins, α-, β- and γ-melanocyte-stimulating hormones (MSHs), are peptides derived from a precursor protein POMC, and play important roles in energy balance, reproductive function, pigmentation and inflammation. MC4 receptors with high affinities for α-MSH and ACTH are expressed almost exclusively in the CNS and appear to play a prominent role in energy homeostasis.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

MC4

Family

Melanocortin receptor

Strain

MC4/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

MC4

Official Name

MC4

Alternative Names

MC4 receptor; MC4R; melanocortin receptor 4; MC4-R

Gene ID

4160(Human); 17202(Mouse); 25635(Rat)

Uniprot ID

P32245(Human); P56450(Mouse); P70596(Rat)

References

1. Mi, G., Liu, S., Zhang, J., Liang, H., Gao, Y., Li, N.,.. & Yang, Z. (2017). Levo-tetrahydroberberrubine produces anxiolytic-like effects in mice through the 5-HT 1A receptor. PloS one, 12(1), e0168964.

Publications