Human CHO-K1/PTH1/Gα15 Stable Cell Line

[CAT#: NCL20120111CR]

Parathyroid Hormone Receptor 1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

It is a G protein coupled receptor which mediates the actions of both amino-terminal PTH and PTHrP fragments. The most abundant expression of PTHR1 is found in renal tubular cells and in osteoblasts, where the PTH/PTHrP receptor mediates the endocrine actions of PTH, and in prehypertrophic chondrocytes of the metaphyseal growth plate, where it mediates the autocrine/paracrine actions of PTHrP. Intact PTH (PTH 1-84) is compounded by a peptide of 84 amino acids (AA), the amino-terminal sequence, constituted by the first 34 AA (N-terminal structure), is necessary for its action.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

PTH1/PTHR1

Family

Parathyroid hormone receptor

Strain

PTH1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

PTH1

Official Name

PTH1

Alternative Names

PTH1 receptor; PPR; PTH/PTHrP receptor; PTH/PTHrP; PTHR; PTHR1; parathyroid hormone receptor 1; PTHrel; Pth1r; PTH/PTHr receptor; PTH/PTHrP type I receptor; Parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone 1 receptor; parathyroid hormone receptor; PTH-related peptide receptor