Creative Biolabs

Mouse NPCNIH Schwann Cells (573C10), Immortalized

[CAT#: NCL-2105-P214-AM]

These cells can be used for disease modeling, drug screening and toxicology testing.

Species:
Mouse
Applications:
Cell Assay
Cell Types:
Schwann Cell

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Description
The immature mouse NPCNIH Schwann cell (573C10) is a spontaneous immortal cell line established from homozygous npcnih/npcnih mice. NPC1 is the gene responsible for most Niemann-Pick disease type C (NPC) patients. In homozygous NPC1 protein was not detected in 573C10 cells. The 573C10 Schwann cell line can be used to study the pathogenesis of NPC neuropathy, the treatment of neurological deficits in NPC patients, and more generally, nerves, cholesterol, and sphingolipids. And the biological system of fatty acid transport.

Expression profile: S100, laminin, p75NTR, GFAP, GM2 ganglioside, Philippine cholesterol cytochemistry
Cell Types
Schwann Cell
Applications
Cell Assay
Application Notes
Cell Cuture:
PriNeu III medium (NCL-2105-P169-AM)
Fetal bovine serum (NCL-2105-P170-AM)
Penicillin/Streptomycin Solution (NCL-2105-P172-AM)
Species
Mouse
Freeze Medium
90% FBS+10% DMSO
Tissue Source
Brain
Cell Purity
>95%
Cell Viability
>90%
Mycoplasma Testing
Negative
Sterility Testing
The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Shipping
Frozen on dry ice
Storage
Liquid nitrogen immediately upon delivery
Research Use Only
For research use only
Quality Control
1) Cytological analysis; 2) Reverse transcription polymerase chain reaction; 3) Western blot
For Research Use Only. Not For Clinical Use.
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