Rat Schwann Cells

Positive for β-III Tubulin

Species:: Rat

Cell Types:: Schwann Cells

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Product Overview

Description

Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the axon membrane to the extracellular space (myelin sheath space) at the Raniver node allows the action potential to propagate quickly along the axon. RSC is important for the morphology, survival and growth of axons and neurons. Studies have also shown that Schwann cells can promote neuronal recovery and experimental spinal cord regeneration.

Cell Types

Schwann Cells

Species

Rat

Properties

Tissue Source

Normal healthy adult rat peripheral nerves

Cell Purity

>95%

Cell Viability

>90%

Mycoplasma Testing

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Sterility Testing

Sterility testing was performed in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Genetic Stability Testing

Cell genetic stability study was perfomed under ICH guidelines. We provide guidance on the appropriate testing program upon your requirements.

Shipping

Dry ice

Storage

Liquid Nitrogen

Handling Advice

Frozen cells: Upon receipt, frozen ampoules should be transferred directly to gaseous phase liquid nitrogen without delay, unless they are to be used straight away.

Growing cells: Growing cell cultures should be checked on receipt using an inverted microscope. Immediately check the cell density upon arrival for any obvious defects. If the cell density is too high (more than 80% confluent) subculture the cells (harvest and reseed) immediately.

For detailed instructions on the thawing procedure of frozen cells and the culture of adherent or suspended cells, please feel free to contact us by email or phone.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents. It is recommended to use cells within ten generations.

Quality Control

No bacteria, yeast, fungi, mycoplasma, virus

Donor Information

Donor Health

Normal

Publications

Publications (0)

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Scientific Resources

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Customer Reviews and Q&As

Customer Reviews Average Customer Ratings Overall

5.0

Excellent

High viability and functional integrity

They demonstrated high viability and purity, which was crucial for our nerve regeneration studies. The cells maintained their morphology and functional characteristics over multiple passages.

Excellent

They exhibited stable growth and differentiation

The cells adhered well to our culture plates and proliferated as expected. The quality control was evident in their consistent growth patterns and robust responses to our treatments.

Excellent

These cells are a great resource

The cells provided were of top-notch quality. They were easy to work with, and their behavior in our assays was very consistent. They played a crucial role in our studies on myelin formation and peripheral nerve injury.

Excellent

We had a positive experience

We found the cells to be highly reliable for our in vitro studies. They showed excellent growth and differentiation capabilities, which were pivotal for our research on nerve cell interactions. The customer service was also outstanding.

Excellent

The cell lines were robust and stable

The schwann cells arrived in perfect condition and were easy to culture. Their ability to myelinate and respond to experimental stimuli was consistent with what we expected.

Q&As

What kind of assays are these schwann cells suitable for?

These rat schwann cells are suitable for a variety of assays including cell proliferation, differentiation, myelination studies, and nerve regeneration assays. They are also used in drug screening and neurobiology research. Ensure that your assay conditions are optimized for schwann cell behavior to achieve reliable results.

Can these cells be used for co-culture experiments with other cell types?

Absolutely, rat schwann cells can be effectively used in co-culture experiments with other cell types such as neurons or fibroblasts. Co-cultures are valuable for studying cell interactions and nerve regeneration. Ensure that you optimize the co-culture conditions for compatibility and desired outcomes.

What are the expected cell growth rates for these schwann cells?

Rat schwann cells typically exhibit a doubling time of approximately 24-48 hours under optimal conditions. Growth rates can vary based on culture conditions, medium composition, and passage number. Regularly monitor cell density and morphology to assess growth and adjust culture conditions as needed.