NeuroMab™ Anti-SPP1 Antibody,Clone NR1374P

Product Overview

Description

The anti-osteopontin antibody can be used for therapeutically treating autoimmune diseases, rheumatism and rheumatoid arthritis.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Chimeric; Humanized

Clone Number

NR1374P

Applications

ELISA; Block; Inhib; In Vitro; In vivo

Relevant Diseases

Alzheimer's Disease; Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

SPP1

Official Name

SPP1

Full Name

Secreted phosphoprotein 1

Alternative Names

BNSP;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;

Gene ID

6696(Human)

Uniprot ID

P10451(Human)

Product Pictures

Inhib

Figure 1 shows a graph depicting the inhibition of RGD-dependent and RGD-independent cell adhesion between nOPN and α9-transformed SW480 cells by murine antibody 2K1.

Experimental results showed that cells treated with S-113-6 antibody had significantly lower cell migration ability than Mork group (PBS) and irrelevant antibody control group within 48 hours.

Inhib

Figure 2 shows a graph depicting inhibition of OPN-induced cell migration by antibodies.

Experimental results showed that cells treated with S-113-6 antibody had significantly lower cell migration ability than Mork group (PBS) and irrelevant antibody control group within 48 hours.

Inhib

Figure 3 shows a graph depicting inhibition of RGD-dependent cell adhesion to OPN.

Experimental results showed that cells treated with S-113-6 antibody had significantly lower cell migration ability than Mork group (PBS) and irrelevant antibody control group within 48 hours.

Publications