Product
NeuroMab™ Anti-Thioredoxin BBB Shuttle Antibody, Clone N245/44
[CAT#: NRZP-0423-ZP426]
- Species Reactivity:
- Wide Species
- Applications:
- ELISA; DB; ICC; WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Thioredoxin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Identified as off-target monoclonal antibody in screen for anti-Stargazin NeuroMabs (immunogen was fusion protein amino acids 203-323, cytoplasmic C-terminus, of rat TARPGamma2). Target identified as Thioredoxin by ELISA and immunoblot against other Thioredoxin fusion proteins.
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Wide Species
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N245/44
Applications
ELISA; DB; ICC; WB
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
Thioredoxin
Official Name
Thioredoxin
Full Name
Thioredoxin
Alternative Names
Thioredoxin; Surface-Associated Sulphydryl Protein; ATL-Derived Factor; SASP; TRX1; TRDX
Uniprot ID
P0AA25
Product Pictures
IB
Fig. 1 Immunoblot against bacterially expressed Thioredoxin (TRX) and/or 6xHistidine (His) tagged fusion proteins.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
