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Creative Biolabs
Product

NeuroMab™ Rat Anti-Trem-2 Monoclonal Antibody (CBP2550)

[CAT#: NAB2007FY940]

Rat Monoclonal [NS78.18] to Trem-2

Host Species:
Rat
Species Reactivity:
Mouse
Applications:
FC

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Product Overview

Description

The rat anti-Mouse TREM-2 antibody, recognizes the trigger receptor expressed on myeloid cell 2 (TREM-2), an activating receptor of the Ig superfamily. TREM-2 and DAP12 form a receptor signaling complex to trigger the activation of immune responses in macrophages and dendritic cells. It may be related to chronic inflammation and may promote the production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 may also have a functional role in the formation of osteoclasts.

Immunogen

Mouse TREM-2 Fc Fusion Protein.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1

Clone Number

CBP2550

Applications

FC

Application Notes

FC: 1/25-1/200

Relevant Diseases

Amyotrophic Lateral Sclerosis; Frontotemporal Dementia

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1859
Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide

Preservatives

YES

Concentration

1 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

TREM2

Official Name

TREM2

Full Name

TREM2 Gene(Protein Coding) Triggering Receptor Expressed On Myeloid Cells 2

Alternative Names

Triggering Receptor Expressed On Myeloid Cells 2; Triggering Receptor Expressed On Myeloid Cells 2a; Triggering Receptor Expressed On Monocytes 2; TREM-2; Trem2a; Trem2b; Trem2c;

Gene ID

54209(Human); 83433(Mouse)

Uniprot ID

Q9NZC2(Human); Q99NH8(Mouse)
References

1. Humphrey, M.B. et al. (2006) TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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