Human CHO-K1/ADRA2A/Gα15 Stable Cell Line

[CAT#: NCL20120020CR]

ADRA2A Adrenoceptors Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

ADRA2A is expressed in the brain, spleen, kidney, aorta, lung, skeletal muscle, heart and liver. ADRA2A -adrenoceptor knockout mice exhibit disruption of presynaptic inhibition of noradrenaline release at high stimulation frequencies. ADRA2A receptor is the principal autoreceptor in the presynaptic feedback loop regulating noradrenaline release. However, another α2 autoreceptor is also present.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

ADRA2A

Family

Adrenoceptors

Strain

ADRA2A/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

ADRA2A

Official Name

ADRA2A

Alternative Names

Alpha 2A-adrenoceptor; adrenergic; alpha-2A receptor; alpha-2AAR subtype C10; Alpha-2A-adrenergic receptor; CA2-47; RATRG20; Adrenergic alpha 2A receptor; Alpha-2AAR; Alpha2A; Adra-2a; Adra-2; alpha2A-AR; ADRA2; ADRA2R; ADRAR; AW122659

Gene ID

150(Human); 11551(Mouse); 25083(Rat)

Uniprot ID

P08913(Human); Q01338(Mouse); P22909(Rat)

References

1. Ghosh, E., Dwivedi, H., Baidya, M., Srivastava, A., Kumari, P., Stepniewski, T.,.. & Roy, D. (2019). Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms. Cell reports, 28(13), 3287-3299. 2. Hernandez-Gordillo, V., & Chmielewski, J. (2014). Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds. Biomaterials, 35(26), 7363-7373.

Publications