Mouse Olfactory Plaque Cells (Op6), Immortalized

[CAT#: NCL-2108P113]

Species:: Mouse

Applications:: Cell Culture

Cell Types:: Olfactory system-related Cells

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Product Overview

Description

Immortalized mouse olfactory substrate cells (OP6) are temperature-sensitive clones from C3H mouse olfactory substrate embryo E10. At an allowable temperature (33C), OP6 expresses a transcription profile that represents the middle and late developmental stages of the olfactory receptor neuron (ORN) lineage, including O/E-1 and BF-1. It does not express olfactory marker protein (OMP), indicating that this is not a mature ORN; however, after 39C differentiation, low levels of OMP were detected. This cell line can also be induced by all-trans retinoic acid to differentiate into mature bipolar ORN-like cell populations.

Cell Types

Olfactory system-related Cells

Applications

Cell Culture

Species

Mouse

Properties

Size

>1x10^6 Cells

Growth Pattern

Adherent

Morphology

Irregular

Immortalization Method

Immortalization by retroviral transduction of U19-tsA58 TAg simian virus 40 large tumor antigen

Freeze Medium

90%FBS+10%DMSO

Tissue Source

Embryo

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

• Each vial contains ≥ 1X10^6 viable cells.
• Cells are tested by PCR and are negative for Hepatitis A, B, C, HPV, Herpes and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.

Publications