NeuroMab™ Anti-Parvalbumin BBB Shuttle Antibody, Clone L114/81

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Parvalbumin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-110 (full-length) of rat Parvalbumin (also known as Parvalbumin alpha, Pvalb and Pva, accession number P02625)
Mouse: 95% identity (104/110 amino acids identical)
Human: 92% identity (101/110 amino acids identical)
~50% identity with Oncomodulin

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

L114/81

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Parvalbumin

Official Name

PVALB

Full Name

Parvalbumin

Alternative Names

Parvalbumin Alpha

Uniprot ID

P02625

Product Pictures

Fig. 1 Array tomography immunofluorescence volume reconstruction of 8 serial LRWhite-embedded 70 nm sections from adult mouse cerebellum with L114/81 (green), rabbit Parvalbumin (Swant PV28, red) and DAPI (blue), with composite overlay (bottom).

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

IHC

Fig. 3 Adult rat thalamus immunohistochemistry.

IHC

Fig. 4 Adult rat somatosensory cortex immunohistochemistry.

Fig. 5 Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with L114/81 (left) or N52A/42 (right) TC supe

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