NeuroMab™ Anti-TDP43 Antibody(NRP-0422-P712)

Product Overview

Description

The rabbit monoclonal NRP-0422-P712 recognizes cytoplasmic aggregates but not recognizes endogenous nuclear WT TDP-43.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rabbit

Applications

ELISA; IHC; ICC; Inhib; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TDP43

Official Name

TDP-43

Full Name

TAR DNA binding protein

Alternative Names

TDP-43; TAR DNA binding protein

Gene ID

23435(Human); 230908(Mouse); 298648(Rat)

Uniprot ID

Q13148(Human); Q921F2(Mouse)

Product Pictures

Figure 1 is a series of images showing the co-localization of rabbit mAb 28H3 staining with cytoplasmic TDP43 aggregates in ANLS-TDP-43 transfected cells but not in ANLS-TDP-43-W68S transfected cells.

Immunofluorescent staining of human TDP-43 and TDP-43 oligomers in brain sections of wild-type and 6- and 12-month-old TDP-43 Tg+/+ transgenic mice. Cells with anti-TDP oligomer staining, TDP-43 staining, and DAPI staining are shown (scale bar, 100 μm). Closed regions are presented at higher magnification in the last column (scale bar, 25 μm).

Publications