iNeu™ Motor Neurons, Isogenic Control
Motor Neurons differentiated from Human iPS cells, frozen
- Species:
- Human
- Cell Types:
- Motor Neuron
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Description
In order to promote ALS/FTD research work, an isogenic model of ALS motor neuron was generated. Using CRISPR gene editing to introduce M337V or Q331K mutations into our iNeu motor neuron parental induced pluripotent stem (iPS) cell line. These gene-edited iPS cells are fully differentiated into high-purity Human cells, showing similar indicators to our apparently healthy iNeu motor neurons.
The isogenic disease model iNeu motor neuron ALS TDP43 M337V and TDP43 Q331K combined with iNeu motor neuron provides a precision medicine-based method that can promote functional genomics research, identification of drug pathways, and the development of co-culture models. They can be used to identify the functional changes and disease mechanisms associated with TDP-43, for drug discovery and the identification of ALS/FTD therapeutic targets, and the development of neuromuscular junction disease models.
Features
iNeu Motor Neurons ALS TDP43 are highly pure cholinergic Human motor neurons that are ≥90% β-III tubulin+/Nestin- and ≥70% Isl1/2 at 14 days in vitro. These proteins also express characteristic markers of motor neurons including Isl1, AchR, C9or72, VAChT, and FoxP1.
Homogenous and reproducible
iNeu Motor Neurons ALS TDP43 undergo rigorous quality control testing ensure the same performance with every batch of cells.
Rapid results
iNeu Motor Neurons ALS TDP43 are shipped cryopreserved with optimized media. Simply thaw and use.
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