NeuroMab™ Anti-Neublastin BBB Shuttle Antibody(NRZP-1022-ZP2454)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

human neublastin (hNBN104)-hIgG1 Fc recombinant protein

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; ELISA; Block; Inhib; In Vitro

Relevant Diseases

Pain

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Artemin

Official Name

ARTN

Full Name

Artemin

Alternative Names

ARTN; ENOVIN; EVN; NBN; artemin; ART

Product Pictures

Inhib

Fig.1 is a scatter plot depicting the ability of anti-hNBN monoclonal antibodies to inhibit NBN-mediated c-RET phosphorylation in murine cells..

The X axis corresponds to the concentration of 3E antibody (Fab) and the Y axis corresponds to NGF binding (percentage of maximum UR). Increased concentrations of Fab E3 blocked the interaction of NGF with both p75 and trkA, as shown by signal reduction (measured in UR). When the concentration of E3 antibody (Fab) was equalized with the concentration of NGF, no NGF binding was observed (as shown by a zero signal).

Publications