Parkinson's Disease (PD) related Cell Products

Since conventional treatments like deep brain stimulation and dopamine replacement therapy can only reduce symptoms and not cure Parkinson's disease (PD), which is a common neurodegenerative disease whose primary pathological feature is the degeneration and death of dopaminergic neurons in the brain's substantia nigra, research into novel treatments—particularly cell-based therapies—has become crucial.

In vitro cell models play an important role in the study of PD. Common in vitro cell models include non-neuronal tumor cell lines, neuronal tumor cell lines, and cell models derived from induced pluripotent stem cells (iPSCs). These models provide important tools for studying the pathogenesis of Parkinson's disease and for drug screening.

At Creative Biolabs, our team has successfully developed human pluripotent stem cell-derived neuron products based on iPSC technology after years of research. In vitro, these cells can be made to develop into either glutamatergic or dopaminergic neurons. Validation data demonstrate the long-term stability and functionality of iPSC-derived dopaminergic neurons in terms of dopamine production and release, thus ensuring the maintenance of motor function.

Please feel free to browse through our related products list to discover the ideal tools for your PD research. For more information about our products or pricing, please contact us.

Explore PD Models Based on Your Research Objective

Alpha-Synuclein LRRK2 Parkin

Alpha-synuclein (α-syn) is a protein that is abundant in the brain, particularly in presynaptic terminals. It is involved in maintaining synaptic function under normal circumstances, but in PD, misfolding and aggregation of α-syn is a major cause of neurodegenerative changes.

Cat. No	Product Name
NCL2110P209	Green Fluorescent Alpha-synuclein SH-SY5Y Cell Line
NCL2110P356	Synuclein A53T Overexpressed SH-SY5Y Cell Line
NCL2110P213	Green Fluorescent Alpha-synuclein U2OS Cell Line
NCL2110P208	Alpha-synuclein Stable Cell Lines

Mutations in the LRRK2 gene are one of the major genetic factors for PD, especially mutations such as G2019S and R1441C, which are highly associated with late-onset PD. These mutations are usually inherited in an autosomal dominant manner and can lead to increased LRRK2 kinase activity, resulting in neurotoxic effects.

Cat. No	Product Name
NCL-2101-ZP15	iNeu^TM Human Neural Stem Cells, LRRK2 G2019S HET
NCL-2101-ZP14	iNeu^TM Human Neural Stem Cells, LRRK2 G2019S HOM

Parkin maintains mitochondrial quality control in cells by recognizing damaged mitochondria and promoting their autophagy. This mechanism is critical for neuronal survival, as mitochondrial dysfunction is a key feature of PD. Parkin is also involved in the ubiquitination and degradation of α-synuclein, which is closely associated with the pathological features of PD.

Cat. No	Product Name
NCL2110P248	Parkin Mitochondrial Recruitment Assay Cell Line
NCL2110P234	Parkin Mitochondrial Recruitment Assay Cell Line [Parkinson's Disease (PD) Model]

The treatment of PD is still full of challenges, but through innovative application research of cell therapy, we are gradually approaching the goal of curing this disease. We recommend our related products and demonstrate our expertise and technical strength in the field of cell therapy. In the future, we look forward to working with more researchers to jointly promote the development of PD treatment.

For Research Use Only. Not For Clinical Use.

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