Parkinson's Disease (PD) related Cell Products
Since conventional treatments like deep brain stimulation and dopamine replacement therapy can only reduce symptoms and not cure Parkinson's disease (PD), which is a common neurodegenerative disease whose primary pathological feature is the degeneration and death of dopaminergic neurons in the brain's substantia nigra, research into novel treatments—particularly cell-based therapies—has become crucial.
In vitro cell models play an important role in the study of PD. Common in vitro cell models include non-neuronal tumor cell lines, neuronal tumor cell lines, and cell models derived from induced pluripotent stem cells (iPSCs). These models provide important tools for studying the pathogenesis of Parkinson's disease and for drug screening.
At Creative Biolabs, our team has successfully developed human pluripotent stem cell-derived neuron products based on iPSC technology after years of research. In vitro, these cells can be made to develop into either glutamatergic or dopaminergic neurons. Validation data demonstrate the long-term stability and functionality of iPSC-derived dopaminergic neurons in terms of dopamine production and release, thus ensuring the maintenance of motor function.
Please feel free to browse through our related products list to discover the ideal tools for your PD research. For more information about our products or pricing, please contact us.
Explore PD Models Based on Your Research Objective
Alpha-synuclein (α-syn) is a protein that is abundant in the brain, particularly in presynaptic terminals. It is involved in maintaining synaptic function under normal circumstances, but in PD, misfolding and aggregation of α-syn is a major cause of neurodegenerative changes.
Cat. No | Product Name |
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NCL2110P209 | Green Fluorescent Alpha-synuclein SH-SY5Y Cell Line |
NCL2110P356 | Synuclein A53T Overexpressed SH-SY5Y Cell Line |
NCL2110P213 | Green Fluorescent Alpha-synuclein U2OS Cell Line |
NCL2110P208 | Alpha-synuclein Stable Cell Lines |
Mutations in the LRRK2 gene are one of the major genetic factors for PD, especially mutations such as G2019S and R1441C, which are highly associated with late-onset PD. These mutations are usually inherited in an autosomal dominant manner and can lead to increased LRRK2 kinase activity, resulting in neurotoxic effects.
Cat. No | Product Name |
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NCL-2101-ZP15 | iNeuTM Human Neural Stem Cells, LRRK2 G2019S HET |
NCL-2101-ZP14 | iNeuTM Human Neural Stem Cells, LRRK2 G2019S HOM |
Parkin maintains mitochondrial quality control in cells by recognizing damaged mitochondria and promoting their autophagy. This mechanism is critical for neuronal survival, as mitochondrial dysfunction is a key feature of PD. Parkin is also involved in the ubiquitination and degradation of α-synuclein, which is closely associated with the pathological features of PD.
Cat. No | Product Name |
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NCL2110P248 | Parkin Mitochondrial Recruitment Assay Cell Line |
NCL2110P234 | Parkin Mitochondrial Recruitment Assay Cell Line [Parkinson's Disease (PD) Model] |
The treatment of PD is still full of challenges, but through innovative application research of cell therapy, we are gradually approaching the goal of curing this disease. We recommend our related products and demonstrate our expertise and technical strength in the field of cell therapy. In the future, we look forward to working with more researchers to jointly promote the development of PD treatment.
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- iNeuMab™ Anti-Alpha Synuclein Antibody (NRP-0422-P614) (Cat#: NRP-0422-P614)
- iNeuMab™ Anti-pTau Antibody (NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Anti-GD2 Antibody (NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- iNeuMab™ Anti-TNFα BBB Shuttle Antibody (NRZP-1022-ZP4105) (Cat#: NRZP-1022-ZP4105)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1760) (Cat#: NRP-0422-P1760)
- iNeuMab™ Anti-ApoC3 BBB Shuttle Antibody (NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Green Fluorescent Tau cell Line (Cat#: NCL2110P219)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
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- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)