Alzheimer's Disease (AD) related Cell Products
Tens of millions of people worldwide suffer from Alzheimer's disease (AD), a neurodegenerative disease characterized by the deposition of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs), which are caused by hyperphosphorylation of tau protein and result in cognitive dysfunction and neuronal death. While there is currently no cure, recent breakthroughs in in vitro cell models and stem cell technology have renewed hope for the treatment of AD.
In vitro cell models are of great value in AD research. These models can simulate the disease process, providing valuable information about disease mechanisms, drug screening, and treatment effects. One such example is the use of hiPSC (induced pluripotent stem cell) technology, which can generate personalized neural network models to assess the impact of drugs on learning and memory. This approach has led to enhanced success rates in translation. The application of 3D tissue engineering and microfluidics technology enhances the authenticity and functionality of these models.
At Creative Biolabs, we have developed a variety of cell line products for Alzheimer's disease research, including neural cell differentiation systems such as hESC and iPSC. These cell lines offer researchers a valuable experimental model, facilitating a deeper understanding of the pathophysiological mechanisms underlying Alzheimer's disease (AD) and paving the way for the development of more effective treatment options.
Please feel free to browse through our related products list to discover the ideal tools for your AD research. For more information about our products or pricing, please contact us.
Explore AD Models Based on Your Research Objective
The relationship between the APOE gene and AD is very strong and is one of the most important genetic risk factors currently being studied. The APOE gene has three major alleles: APOE2, APOE3, and APOE4.
Cat. No | Product Name |
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NCL-2101-ZP06 | iNeuTM Human Neural Stem Cells - Alzheimer's Disease Patient (APOE4 HOM) |
NCL-7P031 | iNeuTM Microglia AD APOE E4/E4 Kit, Donor 1, Disease Model |
NCL-2101-ZP25 | iNeuTM Plated Human Cerebral Cortical Neurons - Alzheimer's Disease Patient (APOE4 HOM) |
Mutations in the PSEN1 gene are one of the most common causes of familial Alzheimer's disease (FAD), especially in early-onset cases.
Cat. No | Product Name |
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NCL-2101-ZP07 | iNeuTM Human Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 L286V) |
NCL-2101-ZP26 | iNeuTM Plated Human Cerebral Cortical Neurons - Alzheimer's Disease Patient (PSEN1 L286V) |
In the brains of patients with AD the tau protein encoded by MAPT is abnormally phosphorylated and forms fibrillar deposits, one of the key pathological features of the disease.
Cat. No | Product Name |
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NCL-2101-ZP16 | iNeuTM Human Neural Stem Cells, MAPT R406W HET |
NRZP-0323-ZP10 | iNeuTM Glutamatergic Neurons MAPT P301S/WT, ALS Model |
There is a strong association between TREM2 (triggered receptor on myeloid cells 2) and Alzheimer's disease (AD). TREM2 is an immunological receptor that is largely expressed on microglia in the central nervous system, and its aberrant function has been connected to the progression of AD.
Cat. No | Product Name |
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NCL-7P014 | iNeuTM Microglia AD TREM2 HO, Disease Model |
NCL-7P015 | iNeuTM Microglia AD TREM2 HZ, Disease Model |
NCL-7P050 | iNeuTM Microglia TREM2 R47H, Donor 10, AHN |
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)