iPSC-derived Neuron and Neural Progenitor Cell (NPC) Generation Services

Human neurons and neural progenitor cells (NPCs) are invaluable models and useful tools for disease mechanism exploration and drug screening. However, obtaining those primary cells poses several challenges, including ethical considerations, limited availability of human tissue, and the difficulty of isolating and maintaining these cells in vitro. The advent of induced pluripotent stem cells (iPSCs) reprogramming technology has overcome this limitation, making the generation of various neurons both easy and efficient. Leveraging our expertise in this cutting-edge field, we are proud to offer researchers the iPSC-derived neurons and neural progenitor cells that facilitate groundbreaking studies in neuroscience.

What We Can Provide

Overview of iPSC Technology

iPSCs are somatic cells reprogrammed to an embryonic stem cell-like state through the introduction of specific transcription factors. The resulting iPSCs retain the ability to differentiate into nearly any cell type in the body, including neurons and neural progenitor cells, which serve as the precursors for mature neurons. By providing a renewable source of these specialized cells, iPSC technology offers significant advantages over traditional methods, such as the use of embryonic stem cells or primary neurons, which can be limited in availability and ethical considerations.

Derivation of Neurons and Neural Progenitor Cells

The process of generating neurons and NPCs from iPSCs typically involves several stages:

Fig.1 NPCs were derived from iPSCs, and these NPCs were subsequently induced to differentiate into neurons.¹

Applications and Importance

• Disease Modeling

hiPSC-derived neurons and NPCs play a pivotal role in advancing neurological research and drug discovery. Their ability to model neurological diseases, such as Alzheimer's and Parkinson's, provides invaluable insights into disease mechanisms and potential therapeutic targets.

• Drug Screening

Furthermore, hiPSC-derived neurons and NPCs enable high-throughput screening of drug candidates, facilitating the identification of neuroprotective compounds. Their use in cellular therapies holds promise for regenerative medicine, potentially offering new treatments for neurodegenerative disorders.

Contact Us Today

Unlock the potential of hiPSC-derived neurons for your research needs. Contact us today to learn more about our services and how we can support your research goals.

Reference

1. Kang, S., Chen, X., Gong, S. et al. "Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern". Sci Rep 7, 12233 (2017), Distributed under CC BY 4.0, without modification.