- NeuroMab™ Anti-Tau Antibody,Clone NR3320P (Cat#: NRP-0422-P1760)
- NeuroMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- NeuroMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-Alpha Synuclein Antibody,Clone NR3861P (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-Tau Antibody,Clone NR1808P (Cat#: NRP-0422-P2293)
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody,Clone NR1707P (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-SEZ6 Antibody, Clone NR28P (Cat#: NRP-0422-P515)
- NeuroMab™ Anti-CD20 Antibody,Clone NR3021P (Cat#: NRP-0422-P1230)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody,Clone NR2660P (Cat#: NRP-0422-P867)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Sf295 Human Glioblastoma Cells (Cat#: NCL-2108P180)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Mouse Hippocampal Neuron Cell HT22 (Cat#: NCL2110P001)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Green Fluorescent Alpha-synuclein SH-SY5Y Cell Line (Cat#: NCL2110P209)
- Human CMEC/D3 Cell Line, Blood-Brain Barrier Model (Cat#: NCL-2108-P020)
- Rat Muller Cell (Cat#: NCL2110P040)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, cTfRMAb-IDUA (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein, HIRMab-NAGLU (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein, cTfRMAb-EPO (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, cTfRMAb-TNFR (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-IDS BBB Shuttle Protein, HIRMab-IDS (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein, HIRMab-SGSH (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-ASA BBB Shuttle Protein, HIRMab-ASA (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, HIRMab-IDUA (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein, HIRMab-PON1 (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein, 8D3-IL-1RA (Cat#: NRZP-0423-ZP497)
Depression Drug Discovery Service
Creative Biolabs is an innovative biotechnology company focused on drug development for depression. Different cellular and animal models of depression are available at Creative Biolabs. Our experienced scientists are dedicated to providing various in vivo and in vitro assays to facilitate the successful delivery of your preclinical drug candidates.
Overview of Depression Drug Discovery
Depression is a serious emotional disorder that threatens the physical and mental health of humans, so depression may impose a heavy economic burden on society. Common symptoms of this disease include chronic low mood, feelings of anxiety, decreased motivation, feelings of worthlessness, and recurring thoughts of death. Furthermore, depression is closely linked to an increased incidence of various diseases, such as stroke, epilepsy, cardiovascular disease, diabetes as well as cancer. Drug therapy is the most common measure for depression treatment. All antidepressants currently in use work primarily to modulate monoamine neurotransmission. Antidepressant increases cell proliferation and granulosa cell survival and reverses the stress-induced reduction in hippocampal neurogenesis. However, this method is not a good cure for depression, since drug resistance and medication adherence are the two major challenges of the treatment. In addition, these drugs take several weeks to exert effects and are effective only in some patients. Therefore, it is imperative to develop a novel concept of an antidepressant that works rapidly and safely in the majority of patients.
Fig.1 Depression Drug Discovery Platform. (Creative Biolabs)
Our Featured Cellular Models
- Primary Neuronal Cell Culture Models
- Human iPSC Derived Neuronal Cell Culture Models
- Organotypic Brain Slice Models
Animal Models of Depression at Creative Biolabs
To accelerate preclinical drug development for depression, diverse animal models were established. Through suitable modeling strategies and behavioral tests, the effect of the target drug can be largely explained. Creative Biolabs provides widely used animal models and modeling services for customers all over the world.
- Reserpine-induced model
Reserpine induces depressive phenotypes by depleting monoamines. This model causes little damage to animals and can effectively distinguish the effects of general antidepressants. What's more, the model is less time-consuming. Therefore, this model is widely used in drug discovery for depression.
- Learned helplessness model
The advantage of this model is that the animals exhibit depressive-like symptoms, essentially covering the onset of depression in humans. Additionally, this model has great potential to study the effect of genetic variation across species on depressive-like symptoms. This model is emerging as an attractive tool for depression drug development.
- Chronic mild stress model
The model has reliable predictive validity and aids in the selection of optimal antidepressants. The model not only mimics the clinical symptoms of most cases of depression in humans but also highlights that anhedonia is a key and measurable feature.
What Can We Do?
- Cell Proliferation and Viability Assays
- Drug combination assay
- Immunoassays
- Functional Assays
- Toxicity Assays
Each modeling method involves different experimental procedures, so each model has pros and cons. Treatment effects are difficult to predict using only a single animal model. For this reason, at Creative Biolabs, our professional scientists will tailor a reasonable solution according to your specific needs. Please contact us in time for more details.