Amyotrophic Lateral Sclerosis (ALS) related Cell Products
Motor neurons are the main target of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS), which causes muscle weakening, atrophy, and ultimately paralysis. There is currently no cure, but studies have shown that in vitro cell models and cell therapies are promising new avenues for the treatment of ALS.
In vitro cell models play an important role in ALS research. These models are able to mimic the pathological features of ALS, such as decreased synaptic protein levels, neuromuscular disconnection, and reduced nerve endings. By improving the generation of hiPSC-derived motor neuron subtypes, the pathological mechanisms of ALS can be better studied and future treatments supported.
Our products include various cell types, such as cell lines, neural stem/progenitor cells and iPSC-derived cells, which can secrete a variety of nerve growth factors, enhance neuroprotection and prevent motor neuron death. In addition, our in vitro models can recapitulate the pathological features of ALS patients, such as decreased synaptic protein concentration and neuromuscular disconnection, providing important support for drug development and optimization of treatment strategies.
Please feel free to browse through our related products list to discover the ideal tools for your ALS research. For more information about our products or pricing, please contact us.
Explore ALS Models Based on Your Research Objective
SOD1 gene mutation is one of the major causes of familial ALS, accounting for approximately 18.9% of familial ALS and 1.2% of sporadic ALS. SOD1 is an antioxidant enzyme whose main function is to scavenge free radicals in cells and protect cells from oxidative damage. However, when SOD1 is mutated, its antioxidant function is weakened, leading to the accumulation of free radicals, which in turn causes mitochondrial dysfunction and neuronal damage.
Cat. No | Product Name |
---|---|
NCL-2105-P133-IX | iNeuTM Human Motor Neurons (SOD1 mutant, A4V, HOM) |
NRZP-0323-ZP42 | iNeuTM Human iPSC, ALS SOD1 H44R, Fibroblast-derived |
NRZP-0323-ZP56 | iNeuTM Human iPSC, ALS SOD1, PBMC-derived |
The relationship between the C9ORF72 gene and ALS is primarily reflected in the expansion of the hexanucleotide repeat sequence (GGGGCC) of the C9ORF72 gene, which is one of the major genetic causes of ALS and frontotemporal dementia (FTD). Expansion of this repeat sequence can lead to multiple pathogenic mechanisms, including RNA toxicity, loss of protein function, and nuclear transport disorders.
Cat. No | Product Name |
---|---|
NCL-2101-ZP35 | iNeuTM Human Motor Neuron Progenitors (C9ORF72 expansion) (Healthy) |
NCL-2101-ZP36 | iNeuTM Human Motor Neuron Progenitors- Amyotrophic Lateral Sclerosis (ALS) (C9ORF72 expansion) |
TDP-43 is a DNA and RNA binding protein involved in RNA processing and gene expression regulation. In ALS patients, TDP-43 often shows abnormal cytoplasmic distribution instead of its normal nuclear localization, and this mislocalization is closely associated with neurodegeneration. Abnormal aggregation and dysfunction of TDP-43 can lead to cytoskeletal dysfunction, disrupted axonal transport, and abnormal accumulation of intracellular vesicles.
Cat. No | Product Name |
---|---|
NCL-2105-P134-IX | iNeuTM Human Motor Neurons (TDP-43 mutation, M337V, HET) |
NCL-2105-P135-IX | iNeuTM Human Motor Neurons (TDP-43 mutation, Q331K, HET) |
NCL-2105-P136-IX | iNeuTM Human Motor Neurons (TDP-43 mutation, M337V, HOM) |
- iNeuMab™ Anti-EPHB2 Antibody (NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Anti-Alpha Synuclein BBB Shuttle Antibody (NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- iNeuMab™ Anti-TREM2 BBB Shuttle Antibody (NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- iNeuMab™ Anti-CD32b Antibody (NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- iNeuMab™ Anti-CD20 Antibody (NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Anti-TREM2 Antibody (NRP-0422-P792) (Cat#: NRP-0422-P792)
- iNeu™ Human Sensory Neurons (Cat#: NCL-2103-P62)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)