Huntington's Disease (HD) related Cell Products

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by mutations in the CAG repeat sequence of the Huntington gene (Htt), resulting in the accumulation of mutant huntingtin protein, leading to neuronal death and neurodegeneration. The pathogenesis of HD involves mitochondrial dysfunction, oxidative stress, abnormal DNA damage repair, and other aspects. In addition, the pathological features of HD include neuronal nuclear aggregation, neurodegeneration, and functional abnormalities of the cortical-striatal pathway.

In the study of HD, in vitro cell models (such as iPSC-derived neurons and microglia) are widely used to simulate disease progression and explore treatment strategies. These models can help researchers better understand the molecular mechanisms of the disease and provide important tools for drug screening and the development of new therapies. For example, iPSC-derived microglia have been used to study the neuroimmunology mechanisms in HD, revealing the key role of microglia in disease progression.

At Creative Biolabs, our in vitro cell products include HD-related neurons, microglia or other related cell types. These products can be used for the study of the molecular mechanism of HD, drug screening, and the development of treatment strategies.

Please feel free to browse through our related products list to discover the ideal tools for your HD research. For more information about our products or pricing, please contact us.

Huntingtin (HTT) Cells

Huntingtin protein is a protein that is highly expressed in the nervous system and has complex and diverse functions. Mutant huntingtin protein triggers the pathological process of HD through multiple mechanisms. For example, it disrupts the dynamic balance of autophagosomes; at the same time, the mutant protein also inhibits mitochondrial function, causing oxidative stress and DNA damage. In addition, the mutant huntingtin protein may further exacerbate neurodegenerative changes by affecting neurotransmitter receptor function, calcium signaling, and dysregulation of intracellular signaling pathways.

Features & Benefits

Our products offer the following advantages:

• High purity and consistency, ensuring the reliability and repeatability of experimental results.
• Functional evaluation, supporting in-depth research on neuronal function, microglial response, etc.
• Disease model construction, assisting researchers in building models that more closely resemble human pathological states, enhancing the clinical relevance of research.