Low Back Pain and Sciatica Drug Discovery Service

Creative Biolabs has been working in the field of life science for over a decade. We integrate global resources to provide a full range of customized one-stop solutions to satisfy your research demands in neuroscience, which promote processes from mechanisms research to clinical transformation studies as well as drug development in low back pain and sciatica.

Background of Low Back Pain and Sciatica

Low back pain is a prevalent and burdensome health problem caused by spinal degeneration and injury and characterized by pain, muscle tension, or stiffness from the costal margin along the hips down to the legs, with or without sciatica. Sciatica results from the irritation, inflammation, injury, pinching, or compression of the sciatic nerve located in the low back, which is the longest and thickest nerve in the human body. In addition to nerve stimulation and injury, neuroinflammation may play a crucial role in low back pain and sciatica. A series of proinflammatory cytokines have been detected in the serum, cerebrospinal fluid, or biopsies of patients with low back pain and sciatica.

The mechanisms of action related to low back pain also include gene mutations and the regulation of neurotransmitter levels (Vlaeyen, 2018). Due to the low back pain has been considered to be nonspecific, there are still bottlenecks in the diagnosis and treatment of low back pain and sciatica. Creative Biolabs is committed to providing low back pain and sciatica assessment services through accurate diagnosis with novel inflammatory biomarkers and finding treatments that focus on patient-specific and modifiable pain mechanisms that have the potential to improve patient outcomes.

Fig.1 Pathophysiological model for chronic low back pain linking somatic and behavioral components. (Langevin, 2007)

Low Back Pain and Sciatica Solutions at Creative Biolabs

Creative Biolabs provides one-stop solution for translational research and integrated research in low back pain and sciatica. A wide range of in vitro, in vivo, and ex vivo assays used to study low back pain and sciatica are available. We are a well-recognized services provider in the field of neural studies equipped with advanced high-throughput imaging and electrophysiology technologies for cell and slice testing, such as neuronal cultures, spinal cord slices, and iPSC-derived sensory neurons, as well as behavioral testing platforms with suitable animal models. Our professional services associated with low back pain and sciatica studies mainly focusing on neuroinflammation include but are not limited to cytokine release assay. In addition, we provide customized discovery and development services to meet your research and drug development requirements in low back pain and sciatica. Developers can screen promising compounds against pro-inflammatory cytokine receptors through our receptor target validation services. Our services enable researchers to better understand the mechanism of action in low back pain and sciatica as well as to discover drug compounds for pain inhibition.

If you have the intention to learn more about our one-stop solutions for preclinical low back pain drug discovery, please don't hesitate to contact us. Our neuroscience experts are pleased to help you to design your programs.

References

1. Vlaeyen, J.W.S.; et al. Low back pain. Nature Reviews Disease Primers. 2018, 4(1): 52.
2. Langevin, H. M.; Sherman, K. J. Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms. Medical hypotheses. 2007, 68(1): 74-80.