Custom Disease/Control iPSC Generation Service

Human induced pluripotent stem cells (iPSCs) have emerged as a powerful tool for studying various diseases, particularly genetic disorders. By reprogramming somatic cells into pluripotent stem cells, researchers can create patient-specific iPSCs that carry the genetic mutations associated with specific diseases. These iPSCs can then be differentiated into various cell types to study disease mechanisms, screen drugs, and develop potential therapies.

Expert scientists at Creative Biolabs are passionate about offering disease-related iPSC-derived cells/mutant iPSCs you need to release you from the stressful and excessive workload process of cell reprogramming - giving you more time to focus on research.

Fig. 1 Use of disease-relevant iPSCs to treat neurological diseases.¹

Our iPSC Disease Models

• Patient-derived iPSC Disease Models

Patient-derived iPSC disease models are reprogrammed from innate somatic cells without any genetic manipulation. These models retain the genetic background of the individual and are reprogrammed to a pluripotent state, thereby providing insights into how diseases manifest in specific patient populations.

• Genetically Engineered iPSC Disease Models

Genetically engineered iPSC disease models involve genetic modifications to introduce specific mutations related to a disease. These models can be generated using techniques such as CRISPR/Cas9 or other gene-editing tools.

• Induced iPSC Disease Models

By introducing exogenous stimuli (e.g., Aβ1-42 peptide), researchers can create disease-like states in iPSC-derived cells, allowing for a better understanding of disease mechanisms, drug responses, and potential therapeutic interventions.

Our iPSC Control Models

• Healthy Control-derived iPSC Models

Healthy control-derived iPSC models are created from somatic cells (like skin or blood cells) of healthy individuals. These cells are reprogrammed into a pluripotent state, allowing them to differentiate into any cell type.

• Isogenic Control iPSC Models

Isogenic control iPSC models are derived from individuals with known genetic backgrounds. These lines are generated by either introducing specific disease-related mutations into healthy iPSCs or by correcting such mutations in patient-derived iPSCs, ensuring that no additional genetic alterations are made.

Disease Model Platforms

We are proud to provide disease-related iPSC-derived cells or mutant iPSCs with you for research use only, which significantly contribute to understanding various pathologies and the development of targeted therapies.

Applications

• Disease Modeling
• Drug Discovery
• Toxicology Studies

Related Services

Reference

1. McTague, Amy et al. "Genome Editing in iPSC-Based Neural Systems: From Disease Models to Future Therapeutic Strategies." Front Genome Ed. 2021;3:630600. Distributed under Open Access license CC BY 4.0. The original image was modified.