Opioid Dependence Drug Discovery Service

Opioid dependence has been recognized as a medical and social problem of concern. For decades, the latest research results on the discovery of new drug targets have opened up new directions for the development of anti-addictive drugs. Creative Biolabs has established an advanced platform, and our scientists are dedicated to providing comprehensive services to clients around the world, especially anti-opioid drug development services.

Overview of Opioid Dependence

Opioids produce pleasant and pain-relieving effects by acting on the nervous system. Opioids include various drugs such as fentanyl, methadone, hydrocodone, codeine as well as morphine. Opioids are secure when properly applied. But when these drugs are abused, it will result in the undesirable consequences of addiction. Opioid dependence is a sophisticated disease with mood swings, depression, decreased motivation, and anxiety as the main symptoms. A variety of factors may contribute to the disease. In addition to genetic, psychological, and environmental roles in addiction, inappropriate use can also have adverse consequences. It is worth noting that the timing of taking opioids is also related to the risk of addiction. Patients are more likely to recover fully with suitable medication-assisted therapy. In recent years, methadone and buprenorphine, the role of opioid agonists in drug addiction, has emerged as a focus. Many patients are treated in primary care, which can provide effective addiction therapy. And evidence showed that methadone, buprenorphine, and naltrexone have favorable effects on opioid use disorder. What's more, the research on new targets of anti-opioid dependence drugs and the development of new drugs has always attracted widespread attention.

Fig.1 Structures of the common opioid drugs. (Franchi, 2019)

What Can We Do?

At Creative Biolabs, our dedicated scientists have expertise in the field of opioid dependence drug discovery and are dedicated to helping you screen the most promising drug candidates. Specializing in standard and custom in vitro and in vivo assays, we focus on providing our clients with flexible solutions with high quality and reproducible data. In addition, we can customize appropriate cell or animal models according to your project needs.

Fig.2 Opioid dependence drug discovery services. (Creative Biolabs)

Our Cellular Models

• 3D Spheroid Cultures
• Primary Neuronal Cell Culture Models
• Human iPSC Derived Neuronal Cell Culture Models

Feature Assays

With an advanced platform and a professional team, Creative Biolabs is committed to providing high-quality and comprehensive customized services to customers around the world, including but not limited to novel anti-opioid dependence therapy development and exploration of the mechanism of action of drugs, providing a strong foundation for preclinical drug screening. If you are interested in our customized cell and animal models, Please contact us promptly for more details.

Reference

1. Franchi, S.; et al. Do all opioid drugs share the same immunomodulatory properties? A review from animal and human studies. Frontiers in Immunology. 2019, 10: 2914.