NeuroMab™ Mouse Anti-ITGAM Monoclonal Antibody (CBP1579)

Product Overview

Description

Mouse anti-human CD11b antibody recognizes human CD11b cell surface glycoprotein, a 165 kDa molecule, also known as alphaM integrin, MAC-1 and CR3. The molecule is expressed as a heterodimer associated with β2 integrin and is present on monocytes, granulocytes, NK cells and some peripheral blood lymphocytes.
According to reports, mouse anti-human CD11b antibodies have multiple functional effects on monocytes, which can block adhesion and stimulate the release of cytokines and chemokines.

Immunogen

Rheumatoid synovial cells and human monocytes.

Species Reactivity

Human; Cynomolgus monkey; Baboon; Rhesus Monkey

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1579

Applications

Relevant Diseases

Alzheimer's Disease

Research Areas

Growth and Development

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1368

Product Properties

Form

Liquid

Formulation

PBS
0.09% Sodium Azide
1% BSA

Purification

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

Target

CD11b

Official Name

ITGAM

Full Name

Integrin alpha M

Alternative Names

ITGAM; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; integrin subunit alpha M

Gene ID

3684 (Human); 16409 (Mouse); 25021 (Rat)

Uniprot ID

P11215 (Human); P05555 (Mouse)

References

1. Malhotra, V. et al. (1986) Ligand binding by the p150,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3).
2. Glasow, A. et al. (2005) Retinoids and myelomonocytic growth factors co-operatively activate RAR{alpha} and induce human myeloid leukemia cell differentiation via MAP kinase pathways.
3. Rezzonico, R. et al. (2001) Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.
4. Rezzonico, R. et al. (2000) Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways.

Publications