Mouse Anti-Human ITGAM Monoclonal Antibody (CBP1534)

Product Overview

Description

Mouse anti-human acetylcholine receptor β antibody, clone B3 has uniform high-affinity binding to the β subunit of nicotinic AChR, which is a complete membrane and cholinergic receptor, consisting of four subunits: α, Δ, γ (immature muscle) and ε (mature muscle).
The combination of the neurotransmitter acetylcholine and AChR causes conformational changes that affect all subunits and initiates the opening of ion conduction channels across the plasma membranes of certain neurons and neuromuscular junctions.

Immunogen

Human Acetylcholine Receptor (AChR).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1534

Applications

FC; IP; IHC-Fr; WB

Application Notes

WB (1/100-1/1000)

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS
0.09% Sodium Azide

Concentration

1 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

CD11b

Official Name

ITGAM

Full Name

Integrin alpha M

Alternative Names

ITGAM; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; integrin subunit alpha M

Gene ID

3684 (Human); 16409 (Mouse); 25021 (Rat)

Uniprot ID

P11215 (Human); P05555 (Mouse)

References

1. Roberts, A. et al. (1992) Search for cross reactive idiotypes on monoclonal and myasthenia gravis acetylcholine receptor antibodies.
2. Heidenreich F. et al. (1988) Differences in fine specificity of anti-acetylcholine receptor antibodies between subgroups of spontaneous myasthenia gravis of recent onset and of penicillamine induced myasthenia.
3. Whiting, P.J. et al. (1986) Myasthenia gravis: monoclonal antihuman acetylcholine receptor antibodies used to analyze antibody specificities and responses to treatment.

Publications