iNeuMab™ Anti-TALK1 potassium channel BBB Shuttle Antibody (NRZP-0423-ZP419)
[CAT#: NRZP-0423-ZP419]
- Species Reactivity:
- Mouse; Rat
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TALK1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 42-94 (first extracellular loop) and 259-292 (cytoplasmic C-terminus) of mouse TALK1 (also known as Potassium channel subfamily K member 16, 2P domain potassium channel Talk-1, TWIK-related alkaline pH-activated K(+) channel 1, Kcnk16, mCG_5959 and rCG_41914, accession number G5E845)
Rat: 100% identity (53/53 amino acids identical) and 91% identity (31/34 amino acids identical)
Human: 94% identity (50/53 amino acids identical) and 67% identity (24/36 amino acids identical)
<50% identity with other potassium channel subunits
Rat: 100% identity (53/53 amino acids identical) and 91% identity (31/34 amino acids identical)
Human: 94% identity (50/53 amino acids identical) and 67% identity (24/36 amino acids identical)
<50% identity with other potassium channel subunits
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
TALK1
Official Name
KCNK16
Full Name
TALK1 potassium channel
Alternative Names
KCNK16; K2p16.1; TALK-1; TALK1; potassium two pore domain channel subfamily K member 16
Uniprot ID
G5E845
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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